IL-1 and TNF Antagonists Inhibit the Inflammatory Response and Bone Loss in Experimental Periodontitis

摘要: Periodontal disease is the most frequent cause of tooth loss in humans and prevalent associated with bone loss, including osteoporosis. destruction initiated by bacteria that colonize surface, leading to inflammation resorption. To assess roles IL-1 TNF this process, studies were conducted a Macaca fascicularis primate model experimental periodontitis. Function-blocking soluble receptors applied local injection sites induced periodontal compared similar injected vehicle alone. The results indicate inhibited approximately 80% recruitment inflammatory cells close proximity bone. formation osteoclasts was reduced 67% at control sites, amount 60%. All statistically significant (p < 0.01). These findings component pathologic process periodontitis due IL-1/TNF activity, since inhibiting reduces both cell loss. data also suggest gingivitis actively protective, blocking further up-regulation host response inhibitors does not damage. Furthermore, these coupled recent evidence participate endocrine-associated osteoporosis multiple pathologies involving excessive may operate through common mechanism and/or TNF.