The therapeutic effects of edaravone on collagen‐induced arthritis in rats

摘要: Current research suggests that synovial phagocytic cells remove excessive amounts of free oxygen radicals (reactive species [ROS]), thereby preventing damage to tissues. Moreover, ROS may affect the expression growth arrest and DNA inducible α (GADD45A), thus further promoting activation fibroblasts. Male adult rats were assessed for progression collagen-induced arthritis (CIA) using a macroscopic scoring system hind paws by measuring changes in rat's body weight, activity level before after diagnosis CIA. Rats intraperitoneally injected twice daily with edaravone at doses 3, 6, 9 mL/kg. Samples taken 2, 4, 6 weeks, respectively. Edaravone was found significantly reduce microscopic pathology scores CIA rats. The concentration endothelial nitric oxide synthase-6, glutathione, heme oxygenase-1 serum decreased, as production around synovium inflammatory factors. ROS-1 increased nuclear factor-κB (NF-κB) p65 protein altering GADD45A, causing aggravation tissue damage. also improved physiological condition rats, including appetite, weight changes, loss fur, well limb mobility. We believe acts NF-ĸB clearing ROS, which causes reduced subsequently reduces apoptosis response proteins, reducing symptoms We, therefore, propose is an effective option clinical treatment rheumatic arthritis.