In vitro and in vivo evaluation of new radiolabeled neurotensin(8–13) analogues with high affinity for NT1 receptors
作者： Elisa García-Garayoa , Lesley Allemann-Tannahill , Peter Bläuenstein , Martine Willmann , Nathalie Carrel-Rémy
DOI: 10.1016/S0969-8051(00)00190-6
关键词:
摘要: The potential utility of neurotensin (NT) in cancer diagnosis and therapy is limited by its rapid degradation. New stabilized analogues were synthesized, labeled with [99mTc] screened vitro vivo. High affinity internalization obtained binding assays. Despite their longer human plasma half-lives, a degradation was observed low concentrations as used biodistribution tests. tumor uptake rates rather but tumor/blood ratios increased according to the stability raise.
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