Biocompatibility of Porous Spherical Calcium Carbonate Microparticles on Hela Cells
作者： Yaran Zhang , Ping Ma , Yao Wang , Juan Du , Qi Zhou
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摘要: Recently there has been a wide concern on inorganic nanoparticles as drug delivery carriers. CaCO3 particles have shown promising potential for the development of carriers drugs, but little research had performed regarding their safe dosage maximizing therapeutic activity without harming biosystems. In this study, we assessed biological safety porous spherical microparticles Hela cells. The reactive oxygen species (ROS), glutathione (GSH), carbonyl content in proteins (CCP), DNA-protein crosslinks (DPC) and cell viability were measured. Results showed that with exposure concentration increase, ROS CCP cells presented significant increase GSH contents decrease respectively compared control. DPC coefficient ascended, no statistically changes observed. results indicated may induce oxidative damage to But other nanomaterials, appeared good biocompatibility. implied calcium carbonate could be applied relatively vehicles, caveat effect high dosages should not ignored when attempting maximize by increasing concentration.
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