Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain

摘要: Though it is clear that genomic variability plays an integral role in accounting for pain sensitivity, controversy exists over which genes are involved. While recent data suggest a “protective” (i.e., less pain) haplotype the GTP cyclohydrolase (GCH1) gene, other research has failed to confirm this association. Possibly, effects of single nucleotide polymorphisms (SNPs) vary depending on task. The current investigation analyzed association five previously identified GCH1 SNPs with ratings induced by topical high concentration (10%) capsaicin applied skin 39 healthy human volunteers. Each was associated lower ratings. When combined, three accounted surprisingly 35% inter-individual variance We conclude gene may profoundly affect capsaicin.