The role of T-cell receptor recognition of peptide:MHC complexes in the formation and activity of Foxp3⁺ regulatory T cells.

摘要: Foxp3(+) regulatory T (Treg) cells are required to prevent the immune system from spontaneously mounting a severe autoaggressive lymphoproliferative disease and can modulate responses in variety of settings, including infections. In this review, we describe studies that use transgenic mice determine how signals through T-cell receptor (TCR) contribute development, differentiation, activity Treg vivo settings. By varying amount quality self-peptide recognized by an autoreactive TCR, have shown interplay between thymocyte deletion cell formation leads repertoire is biased toward low abundance agonist self-peptides. autoimmune setting, demonstrated diverse TCR specificities be order for mouse model inflammatory arthritis. Lastly, initially selected based on specificity activated recognition viral peptide, they acquire specialized phenotype suppress antiviral effector at site infection. These provide insights into pivotal role plays cells.