Clozapine and therapeutic drug monitoring: is there sufficient evidence for an upper threshold?
作者： Gary Remington , Ofer Agid , George Foussias , Larissa Ferguson , Krysta McDonald
DOI: 10.1007/S00213-012-2922-7
关键词:
摘要: Rationale Clozapine levels are advocated in the monitoring of patients on this drug and have now been used for a number years. A safety-related threshold has also proposed, as well therapeutic lower upper thresholds. While there reasonable consensus regarding threshold, is not case
springer.com
sci-hub.se 参考文章(124)
Seizure following addition of erythromycin to clozapine treatment [4] American Journal of Psychiatry. ,vol. 151, pp. 1840- 1841 ,(1994) , 10.1176/AJP.151.12.1840B
Clozapine plasma levels and convulsions. American Journal of Psychiatry. ,vol. 135, pp. 99- 100 ,(1978) , 10.1176/AJP.135.1.99
Kenneth E. Ferslew, Andrea N. Hagardorn, Gretel C. Harlan, William F. McCormick, A Fatal Drug Interaction Between Clozapine and Fluoxetine Journal of Forensic Sciences. ,vol. 43, pp. 1082- 1085 ,(1998) , 10.1520/JFS14363J
Response of patients with treatment-refractory schizophrenia to clozapine within three serum level ranges American Journal of Psychiatry. ,vol. 153, pp. 1579- 1584 ,(1996) , 10.1176/AJP.153.12.1579
Gabriel B K Hung, H K Cheung, Predictors of high-dose antipsychotic prescription in psychiatric patients in Hong Kong. Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine. ,vol. 14, pp. 35- 39 ,(2008)
Relation of leukocyte counts during clozapine treatment to serum concentrations of clozapine and metabolites. American Journal of Psychiatry. ,vol. 152, pp. 610- 612 ,(1995) , 10.1176/AJP.152.4.610
Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients. American Journal of Psychiatry. ,vol. 152, pp. 179- 182 ,(1995) , 10.1176/AJP.152.2.179
J A Frazier, K McKenna, C T Gordon, S C Piscitelli, J L Rapoport, K E Albus, D R Grothe, Plasma clozapine and haloperidol concentrations in adolescents with childhood-onset schizophrenia: association with response. The Journal of Clinical Psychiatry. ,vol. 55, pp. 94- 97 ,(1994)
E E M Brouwers, M Söhne, S Kuipers, E C M van Gorp, J H M Schellens, C H W Koks, J H Beijnen, A D R Huitema, Ciprofloxacin strongly inhibits clozapine metabolism: two case reports. Clinical Drug Investigation. ,vol. 29, pp. 59- 63 ,(2009) , 10.2165/0044011-200929010-00006
Kane Jm, Treatment-resistant schizophrenic patients. The Journal of Clinical Psychiatry. pp. 35- 40 ,(1996)