Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing.

摘要: Mouse macrophages become activated to kill tumor cells by traversing a series of steps (1-3). The first these does not cause the expression cytolytic activity; instead, it primes respond second signal(s) that then triggers onset killing (4-7). mediator is responsible for priming contained, along with other lymphokines, in culture supernatants concanavalin A-stimulated spleen (5-7) cloned T lymphocytes (8), or some cell hybridomas (9). Close association has been noted between macrophage activity and antiviral attributable gamma interferon (10-12). However, unequivocal evidence two activities are products same molecule available. We now how conclusively using mouse (MulFN-gamma)3 produced recombinant DNA technology that, addition activity, this lymphokine capacity induce step process activation killing.