Tumor escape mechanisms in prostate cancer.
作者： Ashley M. Miller , Pavel Pisa
DOI: 10.1007/S00262-005-0110-X
关键词:
摘要: Numerous immunotherapy trials have been carried out in prostate cancer (PC) patients, with induction of antigen-specific T cells some cases. Despite this capability, limited success is seen terms tumor regression or survival. In review, we discuss the evidence for escape strategies that may contribute to vaccine failure setting PC. These include defects antigen presentation, production immunosuppressive substances, cell death, receptor dysfunction, and presence tolerogenic dendritic regulatory inside tumors. It clear novel aimed at preventing escape, such as small molecular weight inhibitors molecules, adoptive transfer TCR transgenic cells, removal Tregs, combined anti-androgen therapy prostate-specific vaccines, need be examined further PC patients.
springer.com
sci-hub.se 参考文章(85)
Yuzo Furuya, Hideki Fuse, Motoyuki Masai, Serum soluble Fas level for detection and staging of prostate cancer. Anticancer Research. ,vol. 21, pp. 3595- 3598 ,(2001)
Salvatori L, Ravenna L, Cardillo Mr, Perracchio L, Di Silverio F, Petrangeli E, Transforming growth factor-beta expression in prostate neoplasia. Analytical and Quantitative Cytology and Histology. ,vol. 22, pp. 1- 10 ,(2000)
Scott, I. Abrams, Positive and negative consequences of Fas/Fas ligand interactions in the antitumor response. Frontiers in Bioscience. ,vol. 10, pp. 809- ,(2005) , 10.2741/1575
Konstantinos Stravodimos, Dimitrios Pantazopoulos, Theodoros Manousakas, Aris Giannopoulos, Constantinos Constantinides, Citi Pavlaki, Constantinos Dimopoulos, Immunohistochemical expression of transforming growth factor beta 1 and nm-23 H1 antioncogene in prostate cancer: divergent correlation with clinicopathological parameters. Anticancer Research. ,vol. 20, pp. 3823- 3828 ,(2000)
Dorothee Gierschner, Ulrich Wetterauer, Arndt Katzenwadel, Wolfgang Schultze-Seemann, Peter Jantscheff, Ursula Elsässer-Beile, Different basal expression of type T1 and T2 cytokines in peripheral lymphocytes of patients with adenocarcinomas and benign hyperplasia of the prostate. Anticancer Research. ,vol. 23, pp. 4027- 4031 ,(2003)
Li Yang, David P. Carbone, Tumor-host immune interactions and dendritic cell dysfunction. Advances in Cancer Research. ,vol. 92, pp. 13- 27 ,(2004) , 10.1016/S0065-230X(04)92002-7
Terry L. Timme, Terry L. Timme, Timothy C. Thompson, Hon Man Lee, Resistance to lysis by cytotoxic T cells: a dominant effect in metastatic mouse prostate cancer cells. Cancer Research. ,vol. 60, pp. 1927- 1933 ,(2000)
A.F. Badawi, The role of prostaglandin synthesis in prostate cancer. BJUI. ,vol. 85, pp. 451- 462 ,(2000) , 10.1046/J.1464-410X.2000.00507.X
Nicholas P. Restifo, Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape Nature Medicine. ,vol. 6, pp. 493- 495 ,(2000) , 10.1038/74955
Shimon Sakaguchi, Noriko Sakaguchi, Misako Itoh, Masanao Asano, Masaaki Toda, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. Journal of Immunology. ,vol. 155, pp. 1151- 1164 ,(1995)