Integrated Transcriptional Maps of Large DNA Regions: Towards a Transcriptional Map of Human Chromosome 21
作者： Marie-Laure Yaspo , Philippe Sanséau , Dean Nizetic , Bernhard Korn , Annemarie Poustka
DOI: 10.1007/978-1-4615-2562-2_19
关键词:
摘要: We present here a relational mapping strategy to establish integrated physical and transcriptional maps of large DNA regions. In this study, human chromosome 21 is used as model because map spanning 40 megabases on the 21q arm has already been achieved. The first step global analysis extract most genic content encoded by chromosome. For purpose, exon-amplification cDNA selection methods are applied in conjunction derive expressed sequence libraries from 21-specific cosmids. These resources will constitute one tools necessary for analysis, allowing cross-screenings between genomic coding libraries. Eventually, new genes represent resource hunt potential candidate implicated determinism severe diseases associated 21.
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