Does 'Immortal DNA strand' exist in 'immortal' stem cells?

摘要: Stem cells function to generate differentiated cells, and, at the same time, are maintained as 'immortal' through self-renewal. Accumulated evidence indicates that adult stem may be most common precursor for cancers in mammalian tissue 1, and this concept is gaining increasing support 2, 3. Meanwhile, also raises question of how which have a much longer lifespan compared other progenitor mature can avoid accumulating mutations from DNA replication errors, thereby reducing risk tumorigenesis. In 1975, J Cairns proposed an intriguing hypothesis evolutionary point view explain phenomenon organisms with long life spans. According 'immortal strand' model, might able retain template (old) strands each asymmetric division accumulation during process 4.