Bactericidal materials prepared via conjugation of responsive polymers to cysteine
作者： Sumbul Hafeez , Jananee Jaishankar , Preeti Srivastava , Leena Nebhani
DOI: 10.1016/J.MTCOMM.2020.101813
关键词:
摘要: Abstract Hybrid bioconjugates based on poly(N-isopropylacrylamide)(PNIPAM)/poly(acrylic acid) (PAA) and cysteine (Cys) (PNIPAM-Cys/PAA-Cys) were synthesized via combination of reversible addition–fragmentation chain-transfer (RAFT) polymerization 2,2,6,6-tetra methylpiperidin-1-yl)oxyl (TEMPO) initiated thiol-ene reaction. In order to use for the preparation these hybrids materials, functionalization with 1,4-bis(acryloyloxy)butane was carried out using TEMPO reaction in an aqueous medium under ambient conditions. The Cys-Ene characterized by 1H 13C NMR spectroscopy Zeta potential measurement. Thiol-functionalized responsive polymers, example, PNIPAM-SH PAA-SH RAFT followed aminolysis resulting thiol terminated polymers functionalized again conditions yield hybrid bioconjugates. materials spectroscopy, UV-visible dynamic light scattering analysis. addition, antibacterial activity evaluated minimum inhibitory concentrations (MICs) found be 70 100 μg/mL against E. coli R. erythropolis respectively. results suggest that constructed because its efficacy towards a broad range bacteria could potentially useful several biomedical applications.
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