The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals.
作者： Hao-Ying Zhang , Jun Xiong , Bao-Ling Qi , Yu-Qi Feng , Bi-Feng Yuan
DOI: 10.1039/C5CC07354E
关键词:
摘要: We developed a novel strategy by oxidation-derivatization combined mass spectrometry analysis for the determination of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA RNA. reported presence RNA mammals found that ascorbic acid hydroquinone can increase oxidation 5-methylcytosine to
rsc.org
sci-hub.se 参考文章(27)
Michael C. Haffner, Alcides Chaux, Alan K. Meeker, David M. Esopi, Jonathan Gerber, Laxmi G. Pellakuru, Antoun Toubaji, Pedram Argani, Christine Iacobuzio-Donahue, William G. Nelson, George J. Netto, Angelo M. De Marzo, Srinivasan Yegnasubramanian, Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers Oncotarget. ,vol. 2, pp. 627- 637 ,(2011) , 10.18632/ONCOTARGET.316
Meng-Dan Lan, Huan Zeng, Fang Zheng, Yu-Qi Feng, Bi-Feng Yuan, Jun Xiong, Han-Peng Jiang, Chun-Yan Peng, Qian-Yun Deng, DNA hydroxymethylation age of human blood determined by capillary hydrophilic-interaction liquid chromatography/mass spectrometry Clinical Epigenetics. ,vol. 7, pp. 72- 72 ,(2015) , 10.1186/S13148-015-0109-X
Yang Tang, Shu-Jian Zheng, Chu-Bo Qi, Yu-Qi Feng, Bi-Feng Yuan, Sensitive and simultaneous determination of 5-methylcytosine and its oxidation products in genomic DNA by chemical derivatization coupled with liquid chromatography-tandem mass spectrometry analysis. Analytical Chemistry. ,vol. 87, pp. 3445- 3452 ,(2015) , 10.1021/AC504786R
Lijuan Fu, Candace R. Guerrero, Na Zhong, Nicholas J. Amato, Yunhua Liu, Shuo Liu, Qian Cai, Debin Ji, Seung-Gi Jin, Laura J. Niedernhofer, Gerd P. Pfeifer, Guo-Liang Xu, Yinsheng Wang, Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA Journal of the American Chemical Society. ,vol. 136, pp. 11582- 11585 ,(2014) , 10.1021/JA505305Z
Magdalena A. Machnicka, Kaja Milanowska, Okan Osman Oglou, Elzbieta Purta, Malgorzata Kurkowska, Anna Olchowik, Witold Januszewski, Sebastian Kalinowski, Stanislaw Dunin-Horkawicz, Kristian M. Rother, Mark Helm, Janusz M. Bujnicki, Henri Grosjean, MODOMICS: a database of RNA modification pathways—2013 update Nucleic Acids Research. ,vol. 41, pp. 262- 267 ,(2012) , 10.1093/NAR/GKS1007
Shinsuke Ito, Li Shen, Qing Dai, Susan C. Wu, Leonard B. Collins, James A. Swenberg, Chuan He, Yi Zhang, Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine Science. ,vol. 333, pp. 1300- 1303 ,(2011) , 10.1126/SCIENCE.1210597
Gerda Egger, Gangning Liang, Ana Aparicio, Peter A. Jones, Epigenetics in human disease and prospects for epigenetic therapy Nature. ,vol. 429, pp. 457- 463 ,(2004) , 10.1038/NATURE02625
Chuan He, Grand Challenge Commentary: RNA epigenetics? Nature Chemical Biology. ,vol. 6, pp. 863- 865 ,(2010) , 10.1038/NCHEMBIO.482
Kathryn Blaschke, Kevin T. Ebata, Mohammad M. Karimi, Jorge A. Zepeda-Martínez, Preeti Goyal, Sahasransu Mahapatra, Angela Tam, Diana J. Laird, Martin Hirst, Anjana Rao, Matthew C. Lorincz, Miguel Ramalho-Santos, Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells Nature. ,vol. 500, pp. 222- 226 ,(2013) , 10.1038/NATURE12362
Yu-Fei He, Bin-Zhong Li, Zheng Li, Peng Liu, Yang Wang, Qingyu Tang, Jianping Ding, Yingying Jia, Zhangcheng Chen, Lin Li, Yan Sun, Xiuxue Li, Qing Dai, Chun-Xiao Song, Kangling Zhang, Chuan He, Guo-Liang Xu, Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA Science. ,vol. 333, pp. 1303- 1307 ,(2011) , 10.1126/SCIENCE.1210944