Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases.

作者: Rita Cascão , João E Fonseca , Luis F Moita , None

DOI: 10.3389/FMED.2017.00069

关键词:

摘要: … of celastrol in diverse clinical areas. Here we systematically review the mechanism of action and the therapeutic properties of celastrol in … and limitations of celastrol formulation, namely, …

参考文章(217)
Jing Sun, Xiao Shen, Jianning Dong, Honggang Wang, Lugen Zuo, Jie Zhao, Weiming Zhu, Yi Li, Jianfeng Gong, Jieshou Li, Tripterygium wilfordii Hook F as Maintenance Treatment for Crohn's Disease The American Journal of the Medical Sciences. ,vol. 350, pp. 345- 351 ,(2015) , 10.1097/MAJ.0000000000000591
Lianjie Lin, Yan Sun, Dongxu Wang, Shihang Zheng, Jing Zhang, Changqing Zheng, Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition. Frontiers in Pharmacology. ,vol. 6, pp. 320- 320 ,(2015) , 10.3389/FPHAR.2015.00320
Li-ping Han, Chun-jun Li, Bei Sun, Yun Xie, Yue Guan, Ze-jun Ma, Li-ming Chen, Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats. Experimental Diabetes Research. ,vol. 2016, pp. 2641248- 2641248 ,(2016) , 10.1155/2016/2641248
Jianquan Guo, Xuemei Huang, Hui Wang, Huanjie Yang, Celastrol Induces Autophagy by Targeting AR/miR-101 in Prostate Cancer Cells PLOS ONE. ,vol. 10, pp. e0140745- ,(2015) , 10.1371/JOURNAL.PONE.0140745
Gerard Aragonès, Andrea Ardid-Ruiz, Maria Ibars, Manuel Suárez, Cinta Bladé, Modulation of leptin resistance by food compounds. Molecular Nutrition & Food Research. ,vol. 60, pp. 1789- 1803 ,(2016) , 10.1002/MNFR.201500964
Xiaodong Liu, Feng Cai, Yan Zhang, Anli Yang, Liang Liu, Celastrol, an NF-κB inhibitor, ameliorates hypercalciuria and articular cartilage lesions in a mouse model of secondary osteoporosis. Journal of Pharmacological Sciences. ,vol. 130, pp. 204- 211 ,(2016) , 10.1016/J.JPHS.2016.02.001
Yikai Li, Yucong Zou, Shiguo Yuan, Pei Zhang, Xian-Wen Yang, Celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro Drug Design Development and Therapy. ,vol. 10, pp. 933- 948 ,(2016) , 10.2147/DDDT.S97463
Renping Wang, Xueqin Gu, Weiquan Dai, Jun Ye, Feng Lu, Yifeng Chai, Guorong Fan, Frank J. Gonzalez, Gengli Duan, Yunpeng Qi, A lipidomics investigation into the intervention of celastrol in experimental colitis Molecular BioSystems. ,vol. 12, pp. 1436- 1444 ,(2016) , 10.1039/C5MB00864F
YUE GUAN, ZI-JIAN CUI, BEI SUN, LI-PING HAN, CHUN-JUN LI, LI-MING CHEN, Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway International Journal of Molecular Medicine. ,vol. 37, pp. 1229- 1238 ,(2016) , 10.3892/IJMM.2016.2549
Xiao-Nan Wang, Qing Wu, Xu Yang, Lian-Sheng Zhang, Yi-Ping Wu, Chong Lu, Effects of Celastrol on growth inhibition of U937 leukemia cells through the regulation of the Notch1/NF-kappaB signaling pathway in vitro. Chinese Journal of Cancer. ,vol. 29, pp. 385- 390 ,(2010) , 10.5732/CJC.009.10526