Antivascular Endothelial Growth Factor Monotherapy for Choroidal Neovascularization Associated With Retinochoroidal Coloboma: Case Series.

作者: Sailaja Bondalapati , Subhadra Jalali , Jay Chhablani

DOI: 10.1097/APO.0000000000000190

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摘要: PURPOSE This study aimed to report the outcomes of antivascular endothelial growth factor (anti-VEGF) monotherapy for choroidal neovascularization (CNVM) associated with retinochoroidal coloboma (RCC). DESIGN A retrospective case series. METHODS was a series 3 eyes CNVM RCC that presented LV Prasad Eye Institute, Hyderabad, India, between January 2006 and 2014. Reported data included demographics, preoperative details (symptoms, duration symptoms, visual acuity), treatment methods, postoperative (visual acuity, follow-up, recurrence). These were compared 9 other cases previously reported in literature. RESULTS Three patients (2 females 1 male) included, mean age 18.3 years (range, 2-32 years). The best corrected acuity ranged from 20/540 20/100. All treated intravitreal bevacizumab injections. number injections 2.0 1-3) follow-up 12 months 4-24 months) no recurrence. at last improved, ranging 20/310 20/60. CONCLUSIONS In view good recurrence lesser injections, anti-VEGF could be considered as coloboma-associated CNVM.

参考文章(17)
Surgical management of retinal detachment with choroidal coloboma. European Journal of Ophthalmology. ,vol. 12, pp. 299- 303 ,(2002) , 10.1177/112067210201200408
Dogra, A Gupta, V Gupta, Subretinal neovascularization associated with retinochoroidal coloboma. Indian Journal of Ophthalmology. ,vol. 45, pp. 116- 117 ,(1997)
Lingam Gopal, Sengamedu S. Badrinath, Tarun Sharma, Sunil N. Parikh, Jyotirmay Biswas, PATTERN OF RETINAL BREAKS AND RETINAL DETACHMENTS IN EYES WITH CHOROIDAL COLOBOMA Ophthalmology. ,vol. 102, pp. 1212- 1217 ,(1995) , 10.1016/S0161-6420(95)30888-3
Alexander Rouvas, Petros Petrou, Maria Douvali, Amalia Ntouraki, Ioannis Vergados, Ilias Georgalas, Nikolaos Markomichelakis, Intravitreal ranibizumab for the treatment of inflammatory choroidal neovascularization. Retina-the Journal of Retinal and Vitreous Diseases. ,vol. 31, pp. 871- 879 ,(2011) , 10.1097/IAE.0B013E3182003CA8
Brandon G. Busbee, Allen C. Ho, David M. Brown, Jeffrey S. Heier, Ivan J. Suñer, Zhengrong Li, Roman G. Rubio, Phillip Lai, Twelve-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration. Ophthalmology. ,vol. 120, pp. 1046- 1056 ,(2013) , 10.1016/J.OPHTHA.2012.10.014
Sun Ho Lee, Jae Kyun Ahn, Hyeong Gon Yu, The development of recurrent choroidal neovascularization in a patient with choroidal coloboma. Korean Journal of Ophthalmology. ,vol. 25, pp. 63- 65 ,(2011) , 10.3341/KJO.2011.25.1.63
Sebastian Wolf, Vilma Jurate Balciuniene, Guna Laganovska, Ugo Menchini, Kyoko Ohno-Matsui, Tarun Sharma, Tien Y Wong, Rufino Silva, Stefan Pilz, Margarita Gekkieva, RADIANCE Study Group, RADIANCE: A Randomized Controlled Study of Ranibizumab in Patients with Choroidal Neovascularization Secondary to Pathologic Myopia Ophthalmology. ,vol. 121, pp. 682- 692 ,(2014) , 10.1016/J.OPHTHA.2013.10.023
Peter Goodwin, Carol L. Shields, Aparna Ramasubramanian, Gary C. Brown, Jerry A. Shields, Ranibizumab for coloboma-related choroidal neovascular membrane in a child Journal of Aapos. ,vol. 13, pp. 616- 617 ,(2009) , 10.1016/J.JAAPOS.2009.09.009
J von Eicken, H Höh, K Rehfeldt, [Photodynamic therapy for choroidal neovascularisation due to choroidal coloboma in a 5 1/2-year-old child]. Klinische Monatsblatter Fur Augenheilkunde. ,vol. 224, pp. 140- 145 ,(2007) , 10.1055/S-2006-927389
Ahmad M. Mansour, Friederike Mackensen, J. Fernando Arevalo, Focke Ziemssen, Padmamalini Mahendradas, Abla Mehio-Sibai, Nicholas Hrisomalos, Timothy Y.Y. Lai, David Dodwell, Wai-Man Chan, Thomas Ness, Alay S. Banker, Sivakami A. Pai, Maria H. Berrocal, Rania Tohme, Arnd Heiligenhaus, Ziad F. Bashshur, Moncef Khairallah, Khalil M. Salem, Frank N. Hrisomalos, Matthew H. Wood, Wilson Heriot, Alfredo Adan, Atul Kumar, Lyndell Lim, Anthony Hall, Matthias Becker, Intravitreal bevacizumab in inflammatory ocular neovascularization American Journal of Ophthalmology. ,vol. 146, pp. 410- 416 ,(2008) , 10.1016/J.AJO.2008.05.024