Lynch syndrome screening in endometrial cancer patients with immunohistochemistry: A single center experience

摘要: Objectives: Universal screening for Lynch syndrome (LS) using immunohistochemistry (IHC) is recommended patients with new colon cancer. While the sentinel malignancy in women equally as likely to be endometrial cancer compared cancer, universal has not been implemented on such a large scale. Our study aims determine any associations between loss of MMR expression and tumor clinico-pathologic characteristics, well number germ line mutations identified IHC at our institution. Methods: A retrospective review who underwent hysterectomy grade 1 or 2 endometrioid August 2012 January 2014 was performed. Only deficiencies MLH1, MSH2, MSH6, PMS2 were included this cohort. Patient charts reviewed patient demographics, size, grade, invasion, stainingwere abstracted from electronic medical records. Results: 180 low EEC during period. Of these, 102 (56.6%) had evaluate protein deficiencies. Twenty six (25.5%) tumors detected via IHC, 19 (18.6%) having MLH1/ 3 (2.9%) MSH2/MSH6. Loss single observed 4 patients, MSH6 noted (2.0%) MLH1 (1%) each. promoter methylation analysis performed 7 (35.0%) 20 tumors, showing 6 (85.7%). One MSH2 by found have germline mutation MSH6. Grade significantly associated multivariate (OR 5.3, p = 0.012, 95% CI 1.4–19.8). Increasing age 1.2, 0.021, 1.0– 1.3). Younger 0.79, 0.025, .64–.97). Conclusions: The most common deficiency involves age. younger Large studies cost-effectiveness analyses must if implementation standardized regimen necessary.