A new approach to the synthesis of 2-aryl-substituted benzimidazoles, quinazolines, and other related compounds and their antibacterial activity
作者： Renata Los , Marta Wesołowska-Trojanowska , Anna Malm , Monika M. Karpińska , Joanna Matysiak
DOI: 10.1002/HC.21012
关键词:
摘要: A new synthesis method of benzimidazoles, dihydroquinazolines, and other related compounds containing a 2,4-dihydroxyphenyl moiety was elaborated. Their structures were identified from elemental, infrared, 1H NMR, 13C mass spectra analyses. The minimal inhibitory concentration values the toward eight reference bacterial strains determined by two-fold serial microdilution broth method. exhibited substantial effects against Gram-positive tested contrary to Gram-negative ones. imidazopyridine, N-methylbenzimidazole, dihydroquinazoline largest activity. magnification covering two-nitrogen atom heterocyclic ring fused benzene one decreases biological effect. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:265–275, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21012
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