The cancer COMPASS: navigating the functions of MLL complexes in cancer.
作者： David J. Ford , Andrew K. Dingwall
DOI: 10.1016/J.CANCERGEN.2015.01.005
关键词:
摘要: The mixed-lineage leukemia family of histone methyltransferases ( MLL1–4 , or KMT2A–D ) were previously linked to cancer through the founding member, MLL1/KMT2A which is often involved in translocation-associated gene fusion events childhood leukemias. However, recent years, a multitude tumor exome sequencing studies have revealed that orthologues MLL3/KMT2C and MLL2/KMT2D are mutated significant percentage large variety malignancies, particularly solid tumors. These unexpected findings necessitate deeper inspection into activities functional differences between MLL/KMT2 members. This review provides an overview this protein its relation cancers, focusing on links MLL2/4/KMT2D their potential roles as suppressors assortment cell types.
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