Changes in glutathione-related enzymes in tumor-bearing mice after cisplatin treatment.

摘要: The effect of cisplatin on five glutathione-related enzymes was studied in liver, kidney, and Dalton lymphoma cells tumor-bearing mice. In the activities glutathione S-transferase, peroxidase, catalase, superoxide dismutase decreased approximately 30-40%, 60-67%, 35-50% 70-80% respectively, while reductase increased about 36-45% after treatment. catalase activity by 47-82% at all time points (24-96 h) treatment, S-transferase significantly (approximately 24%) mainly 72 h An increase 1.5-2.5 times), peroxidase (significant 24 h, 47%), 15-60%) noted kidney cells, very distinctly 2-5, 2-5 5-11 times, respectively) points, but only Interestingly, initially 24-48 then 60%) during later periods (72-96 Cisplatin treatment caused a decrease level 14-20%) 18-28%) no change liver. view results, definite correlation with changes concentrations enzymatic tissue could not be firmly derived. It is suggested that various levels tissues host cisplatin-mediated chemotherapy affect cellular antioxidant defense potential, which may play an important contributory role toxicity, particularly nephrotoxicity, anticancer host.