TYPE I INTERFERONS (/) IN IMMUNITY AND AUTOIMMUNITY

摘要: ■ Abstract The significance of type I interferons (IFN-α/β) in biology and medicine renders research on their activities continuously relevant to our understanding normal abnormal (auto) immune responses. This relevance is bolstered by discoveries that unambiguously establish IFN-α/β, among the multitude cytokines, as dominant defining qualitative quantitative characteristics innate adaptive processes. Recent advances elucidating these key cytokines include better definition complex signaling pathways, determination importance modifying effects other role Toll-like receptors induction, major cellular producers, broad diverse impact both humoral Consequently, IFN-α/β pathogenesis autoimmunity remains at forefront scientific inquiry has begun illuminate mechanisms which molecules promote or inhibit systemic organ-specific autoimmune diseases.