作者: X.-J. Xu , C.A. Maggi , Z. Wiesenfeld-Hallin
DOI: 10.1016/0306-4522(91)90071-U
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摘要: The effects of intrathecal administration neurokinin A, substance P and [Tyr5, D-Trp6,8,9 Arg10]neurokinin A-(4-10) (Men 10207), a specific NK-2 receptor antagonist, on the spinal nociceptive flexor reflex were studied in decerebrate, spinalized, unanesthetized rats. Intrathecal A facilitate similar manner. facilitation to but not P, is dose-dependently blocked by pretreatment with Men 10207. antagonist itself facilitates potency about 10 times less than that indicating partial agonistic property. Reversible depression reflex, which due nonspecific blockade, observed after 700 pmol Further increasing dose 10207 7 nmol for 20 s at an intensity activates unmyelinated (C) fibers stimulation peripheral nerves 1 Hz ipsilateral reflex. duration conditioning cutaneous sural nerve several minutes h gastrocnemius muscle nerves. Pretreatment (70-700 pmol) has no effect stimulation, effectively blocks long-term stimulation. present results indicate distinct role tachykinin receptors mediation excitability rat. Neurokinin may be involved increase activation innervating muscle.