Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice

摘要: Oxidative stress and inflammation are crucial factors that increase with age. In the progression of multiple age-related diseases, antioxidants bioactive compounds have been recognized as useful antiaging agents. Oxidized or reduced vitamin C exerts different actions on tissues has metabolism uptake. this study, we analyzed effect C, both oxidized forms, in renal aging using laser microdissection, quantitative reverse-transcription polymerase chain reaction, immunohistochemical analyses. kidneys old SAM mice (10 months age), a model accelerated senescence, especially form (dehydroascorbic acid [DHA]) improves histology function. Serum creatinine levels microalbuminuria also decrease after treatment decline azotemia. addition, sodium-vitamin cotransporter isoform 1 levels, which were increased during aging, normalized. contrast, pattern glucose transporter expression is not affected by treatment. We conclude potent therapies DHA reverses kidney damage observed senescence-accelerated prone mouse 8 to greater degree.