Genetics of Preeclampsia: What are the Challenges?

摘要: Abstract Despite recent efforts to identify susceptibility genes of preeclampsia, the genetic determinants condition remain ill-defined, as is situation for most disorders complex inheritance patterns. The angiotensinogen, factor V, and methylenetetrahydrofolate reductase have been investigated in different populations, other involved blood pressure, vascular volume control, thrombophilia, lipid metabolism, oxidative stress, endothelial dysfunction. study genetics traits faced with both methodological issues; these include adequate sample size allow identification modest effects, gene-gene gene-environment interactions, quantitative extreme phenotypes, haplotype analyses, statistical genetics, genome-wide (hypothesis- free) versus candidate-gene (hypothesis-driven) approaches, validation positive associations. use genetically well-characterized populations showing a founder effect, such French-Canadian population Quebec, association studies, may help unravel inheritance, preeclampsia. It necessary better evaluate role fetal genome resulting predisposition preeclampsia its complications. Eventually, we be able integrate information women at risk developing improve management those suffering from this condition.