Measurement of airway responsiveness to methacholine: relative importance of the precision of drug delivery and the method of assessing response.
作者： J R Beach , C L Young , A J Avery , S C Stenton , J H Dennis
DOI: 10.1136/THX.48.3.239
关键词:
摘要: BACKGROUND: The value of measuring airway responsiveness in asthma research is currently limited by the number different methods used investigators, lack a standardised method expressing precision, and an inability to equate results one with those another. METHODS: Two pairs measurements methacholine were performed 20 asthmatic subjects, pair using dosimeter (AR-D) conventional Wright nebuliser tidal breathing (AR-W). two normally use techniques for quantifying changing levels forced expiratory volume second (FEV1) after each dose (the mean highest three six AR-D, lower AR-W), provoking (PD20) concentration (PC20) respectively responsible 20% decrement FEV1). RESULTS: coefficient repeatability (and hence precision) measurement was significantly better AR-D (3.0) than AR-W (10.9), but technique FEV1 contributed more this delivering methacholine. A PC20 1 mg/ml equivalent PD20 103 micrograms AR-D. CONCLUSIONS: It practical as well desirable compare precision derive conversion factors so that may be equated.
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