Simultaneous determination of four antipsychotic drugs in plasma by high-performance liquid chromatography. Application to management of acute intoxications.
作者： L Garay Garcia , I Forfar-Bares , F Pehourcq , C Jarry
DOI: 10.1016/S1570-0232(03)00576-2
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摘要: Abstract A specific reversed phase-high pressure liquid chromatography (RP-HPLC) method has been developed for the simultaneous determination of clozapine (CZP), loxapine (LXP), zuclopenthixol (ZPT) and flupenthixol (FPT) in plasma. These four antipsychotic drugs are frequently used treatment schizophrenia other neuropsychiatric diseases. Carpipramine, a dihydrodibenzazepine, was as an internal standard (I.S.). liquid–liquid procedure to extract from human The analysis performed on XTerra™ MS C 18 column with UV detection. Calibration curves were linear range 50–1000 μg/l. limit quantification (LOQ) 15 μg/l 20 μg/l flupenthixol. coefficient variation (CV) intra- inter-day precision 7.2% or less accuracies within 10% three concentrations. This isocratic rapid (run time
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