Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress.

摘要: Non-alcoholic fatty liver disease (NAFLD) is one of the most common manifestations chronic worldwide. The aim present study was to assess effect resveratrol on fat accumulation, as well activity those enzymes involved in lipogenesis and acid oxidation fa/fa Zucker rats. A total thirty rats were assigned three experimental groups orally treated with for 6 weeks, or without (C: control group; RSV15 group: 15 mg/kg body weight per d; RSV45 45 mg/kg d). Liver histological analysis performed by microscopy. Levels hepatic carnitine palmitoyltransferase-Ia (CPT-Ia), acyl-coenzyme oxidase (ACO), synthase, glucose-6-phosphate dehydrogenase malic enzyme assessed spectrophotometry, acetyl-CoA carboxylase radiometry. Commercial kits used determine serum TAG, NEFA, HDL non-HDL-cholesterol, glycerol, ketonic bodies, glucose, insulin, adiponectin, aspartate aminotransferase (AST), alanine (ALT) alkaline phosphatase (ALP), thiobarbituric reactive substrates, GSH (GSSG) superoxide dismutase. Resveratrol reduced TAG content. It did not modify lipogenic but it increase CPT-Ia ACO activities. NEFA ALP both resveratrol-treated groups. AST/GOT only lowest dose. ALT/GPT, adiponectin remained unchanged. oxidative stress. This demonstrates that can protect from NAFLD reducing availability. Moreover, also protects