Endothelial progenitor cells in diabetic foot syndrome.

摘要: In the late 20 th century endothelial progenitor cells (EPCs) were discovered and identified as capable of differentiating into cells. Antigens characteristic hematopoietic are located on their surface. EPCs can proliferate, adhere, migrate have specific ability to form vascular structure, they a wide range roles: They participate in maintaining hemostasis, play an important part processes vasculogenesis angiogenesis. sources angiogenic factors, especially growth factor (VEGF). exist bone marrow, from which recruited circulation response stimuli. Tissue ischemia is thought be strongest inductor EPC mobilization. Local accompanies many pathological states, including diabetic foot syndrome (DFS). Impaired angiogenesis – typical DFS. An analysis available literature indicates that patients number declines functioning impaired. Endothelial crucial during ischemic neovascularization. The pathomechanisms underlying impaired with DFS complicated, but discovery has shed new light pathogenesis diseases, diabetes (Adv Clin Exp Med 2012, 21, 2, 249–254).