Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection.

作者: Jacques Fantini , Coralie Di Scala , Henri Chahinian , Nouara Yahi

DOI: 10.1016/J.IJANTIMICAG.2020.105960

关键词:

摘要: … or its more active derivative, hydroxychloroquine (CLQ-OH)], the viral S protein is no longer able to bind gangliosides. The identification of this new mechanism of action of CLQ and CLQ…

参考文章(30)
Mikhail Matrosovich, Georg Herrler, Hans Dieter Klenk, Sialic Acid Receptors of Viruses Topics in Current Chemistry. ,vol. 367, pp. 1- 28 ,(2013) , 10.1007/128_2013_466
Wenhui Li, Michael J. Moore, Natalya Vasilieva, Jianhua Sui, Swee Kee Wong, Michael A. Berne, Mohan Somasundaran, John L. Sullivan, Katherine Luzuriaga, Thomas C. Greenough, Hyeryun Choe, Michael Farzan, Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. ,vol. 426, pp. 450- 454 ,(2003) , 10.1038/NATURE02145
Radhia Mahfoud, Nicolas Garmy, Marc Maresca, Nouara Yahi, Antoine Puigserver, Jacques Fantini, Identification of a Common Sphingolipid-binding Domain in Alzheimer, Prion, and HIV-1 Proteins Journal of Biological Chemistry. ,vol. 277, pp. 11292- 11296 ,(2002) , 10.1074/JBC.M111679200
Andrea Savarino, Livia Di Trani, Isabella Donatelli, Roberto Cauda, Antonio Cassone, New insights into the antiviral effects of chloroquine Lancet Infectious Diseases. ,vol. 6, pp. 67- 69 ,(2006) , 10.1016/S1473-3099(06)70361-9
Yanning Lu, Ding Xiang Liu, James P. Tam, Lipid rafts are involved in SARS-CoV entry into Vero E6 cells. Biochemical and Biophysical Research Communications. ,vol. 369, pp. 344- 349 ,(2008) , 10.1016/J.BBRC.2008.02.023
Martin J Vincent, Eric Bergeron, Suzanne Benjannet, Bobbie R Erickson, Pierre E Rollin, Thomas G Ksiazek, Nabil G Seidah, Stuart T Nichol, Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Virology Journal. ,vol. 2, pp. 69- 69 ,(2005) , 10.1186/1743-422X-2-69
Olgun Guvench, Shannon N. Greene, Ganesh Kamath, John W. Brady, Richard M. Venable, Richard W. Pastor, Alexander D. Mackerell, Additive empirical force field for hexopyranose monosaccharides Journal of Computational Chemistry. ,vol. 29, pp. 2543- 2564 ,(2008) , 10.1002/JCC.21004
Asher Mullard, Drug repurposing programmes get lift off Nature Reviews Drug Discovery. ,vol. 11, pp. 505- 506 ,(2012) , 10.1038/NRD3776