Toxic Hydroperoxides in Intravenous Lipid Emulsions Used in Preterm Infants

摘要: The unsaturated fatty acids that make up a large component of the lipid emulsion Intralipid are highly susceptible to peroxidation, and products this reaction could explain toxicity has been associated with administration some emulsions. Lipid peroxidation produces hydroperoxides, which can alter arachidonic acid metabolism or react form organic free radicals, then stimulate cascade damage endogenous lipids. hydroperoxides their breakdown also mutagens carcinogens. To determine degree in Intralipid, we measured hydroperoxide content three lots 20% using high-performance liquid chromatography chemiluminescence detection. average concentration was 290 +/- 29 mumol/L (SEM) (n = 15), portion made trilinoleate derivatives. Measurements on samples collected from end intravenous tubing after 20-hour infusion cycle were not significantly different measurements newly opened bottles. emulsions may represent clinically significant risk premature infants, particularly those preexisting lung disease.