Early onset alcohol dependence with high density of family history is not “male limited”

摘要: Abstract Objective Based on classical adoption studies, early onset type II alcoholism was originally described as “male limited.” We examined the possible expression of this subtype in present day alcohol-dependent women. Detailed systematic assessment obtained from 200 treatment-seeking women and 189 healthy population controls. Women fulfilling criteria had higher severity measured by The Alcohol Use Disorders Identification Test markedly use illicit drugs. Both subtypes scored than normal anxiety impulsivity traits, but aggression subscales either other groups. Importantly, density family history women, suggesting a heritability. Despite its original description male limited, with high is likely to be valid construct Its recognition has important implications for diagnosis, treatment, research.