Antipsychotic Use Among Adult Outpatients and Venous Thromboembolic Disease

摘要: Background Treatment with antipsychotic (AP) agents is associated incident thromboembolic events. However, the underpinnings of this association remain unknown. We sought to evaluate effect AP agents-categorized by their metabolic/sedative and hyperprolactinemia adverse profile-on risk venous disease during long-term follow-up. Methods A retrospective cohort study adult patients initiating treatment for first time was conducted. Primary outcome defined as thromboembolism (VTE) (either deep thrombosis or acute pulmonary embolism). Antipsychotic were categorized (high vs low) either drug-induced (a) sedation/metabolic event (b) hyperprolactinemia. used a propensity score-adjusted Cox proportional hazards model control confounding. Findings One thousand eight (mean age, 72.4 y) followed median 36 months. Incident VTE occurred in 6.25% patients, corresponding an incidence rate 184 cases per 10,000 person-years. found no difference hazard follow-up between high- low-risk groups (hazard ratio, 1.23 [95% confidence interval, 0.74-2.04] categories, ratio 0.81 0.50-1.35] high versus low risk). Conclusions These results suggest that events older adults who started does not seem be related these drugs' remains common problem subgroup patients.