Prednisone in the Treatment of Allergic Diseases in Children

摘要: Two recently synthesized and developed steroid hormones, prednisone prednisolone, have given promise of having all the advantages their precursors, cortisone hydrocortisone, while obviating many undesirable side-effects older preparations.1,2These side-effects, which were noticeable even with short-term use preparations, included sodium water retention, potassium depletion, moon facies, hypertension. Prednisone is an analogue cortisone, whereas prednisolone a similar hydrocortisone. They are obtained by dehydrogenation carbon atoms in Positions 1 2 nucleus, resulting double bond between C1and C2(Fig.). Clinically, they appear to from three five times effect two four hydrocortisone.3,4There appears be little difference clinical effectiveness or dosage prednisolone.3-5Therefore,