Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists.
作者： E. Bona , U. Ådén , E. Gilland , B.B. Fredholm , H. Hagberg
DOI: 10.1016/S0028-3908(97)00139-1
关键词:
摘要: The effects of nonselective (theophylline). A 1 - (DPCPX) or 2A -selective (SCH 58261) adenosine receptor antagonists administered before after neonatal hypoxia-ischemia (HI) were studied on the extent brain injury in 7-day-old rats evaluated 14 days. possible effect theophylline (20 mg/kg) expression immediate early genes was with situ hybridization. Theophylline (20, 30 60 given prior to HI reduced damage by 48% (P < 0.001), 36% 0.01) and 34% 0.05), respectively, compared control rats. This not explained changes temperature, cerebral blood flow, gas/acid base status glucose during insult. enhanced upregulation c-fos NFGI-A reperfusion but did prevent decrease mRNA. Posttreatment SCH 58261 (0.2 2 19% (P<0.05) 14% (NS), which unrelated core temperature. DPCPX (2 10 had no development injury. In conclusion, a model immature animals.
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