Induction of classical transplantation tolerance in the adult.
作者： S X Qin , S Cobbold , R Benjamin , H Waldmann
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摘要: Transplantation tolerance across histoincompatibilities in multiple non-H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A antigens has been achieved successfully by combined adult bone marrow transplantation treatment with CD4 CD8 mAbs. The tolerant state was confirmed permanent acceptance of donor strain skin grafts, vitro unresponsiveness to cells. Tolerance associated partial chimerism various degrees. minor induced this manner restricted recipient-type MHC. possibility raised that resulted, at least part, from clonal anergy rather than deletion.
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