NDP-α-MSH induces intense neurogenesis and cognitive recovery in Alzheimer transgenic mice through activation of melanocortin MC4 receptors.
作者： Daniela Giuliani , Laura Neri , Fabrizio Canalini , Anita Calevro , Alessandra Ottani
DOI: 10.1016/J.MCN.2015.05.004
关键词:
摘要: Melanocortins exert neuroprotection in a variety of experimental neurodegenerative disorders, including Alzheimer's disease (AD). Further, in previous research we showed that these endogenous peptides stimulate neurogenesis in an acute neurodegenerative disorder such as ischemic stroke. In the present research, we investigated the potential neurogenic effect of melanocortins in AD using APP Swe transgenic mice (Tg2576). To this purpose, 24 week-old animals were prepared for 5-bromo-2′-deoxyuridine (BrdU) labeling of …
core.ac.uk
sci-hub.se 参考文章(68)
Kathleen G. Mountjoy, Distribution and Function of Melanocortin Receptors within the Brain Advances in Experimental Medicine and Biology. ,vol. 681, pp. 29- 48 ,(2010) , 10.1007/978-1-4419-6354-3_3
Daniela Giuliani, Maria Galantucci, Laura Neri, Fabrizio Canalini, Anita Calevro, Alessandra Bitto, Alessandra Ottani, Eleonora Vandini, Paola Sena, Maurizio Sandrini, Francesco Squadrito, Davide Zaffe, Salvatore Guarini, Melanocortins protect against brain damage and counteract cognitive decline in a transgenic mouse model of moderate Alzheimer׳s disease European Journal of Pharmacology. ,vol. 740, pp. 144- 150 ,(2014) , 10.1016/J.EJPHAR.2014.06.063
Luca Spaccapelo, Alessandra Bitto, Maria Galantucci, Alessandra Ottani, Natasha Irrera, Letteria Minutoli, Domenica Altavilla, Ettore Novellino, Paolo Grieco, Davide Zaffe, Francesco Squadrito, Daniela Giuliani, Salvatore Guarini, Melanocortin MC4 receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia European Journal of Pharmacology. ,vol. 670, pp. 479- 486 ,(2011) , 10.1016/J.EJPHAR.2011.09.015
Salvatore Guarini, Carla Bazzani, Guido Mattera Ricigliano, Anna Bini, Aldo Tomasi, Alfio Bertolini, Influence of ACTH-(1-24) on free radical levels in the blood of haemorrhage-shocked rats: direct ex vivo detection by electron spin resonance spectrometry. British Journal of Pharmacology. ,vol. 119, pp. 29- 34 ,(1996) , 10.1111/J.1476-5381.1996.TB15673.X
Salvatore Oddo, Antonella Caccamo, Jason D Shepherd, M.Paul Murphy, Todd E Golde, Rakez Kayed, Raju Metherate, Mark P Mattson, Yama Akbari, Frank M LaFerla, Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Neuron. ,vol. 39, pp. 409- 421 ,(2003) , 10.1016/S0896-6273(03)00434-3
Haythum O. Tayeb, Hyun Duk Yang, Bruce H. Price, Frank I. Tarazi, Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors Pharmacology & Therapeutics. ,vol. 134, pp. 8- 25 ,(2012) , 10.1016/J.PHARMTHERA.2011.12.002
Stefano Gatti, Caterina Lonati, Francesco Acerbi, Andrea Sordi, Patrizia Leonardi, Andrea Carlin, Sergio M. Gaini, Anna Catania, Protective action of NDP-MSH in experimental subarachnoid hemorrhage. Experimental Neurology. ,vol. 234, pp. 230- 238 ,(2012) , 10.1016/J.EXPNEUROL.2011.12.039
Daniela Giuliani, Alessandra Ottani, Letteria Minutoli, Vincenzo Di Stefano, Maria Galantucci, Alessandra Bitto, Davide Zaffe, Domenica Altavilla, Annibale R. Botticelli, Francesco Squadrito, Salvatore Guarini, Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268. Brain Behavior and Immunity. ,vol. 23, pp. 844- 850 ,(2009) , 10.1016/J.BBI.2009.03.009
Jarl E. S. Wikberg, Felikss Mutulis, Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction Nature Reviews Drug Discovery. ,vol. 7, pp. 307- 323 ,(2008) , 10.1038/NRD2331
Orly Lazarov, Mark P. Mattson, Daniel A. Peterson, Sanjay W. Pimplikar, Henriette van Praag, When Neurogenesis Encounters Aging and Disease Trends in Neurosciences. ,vol. 33, pp. 569- 579 ,(2010) , 10.1016/J.TINS.2010.09.003