Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration.

摘要: For investigation of the pathogenesis cerebral malaria, immediate postmortem samples from brain and other tissues patients dying with Plasmodium falciparum (CM) or without (NCM) were processed for electron microscopy. Counts parasitized erythrocytes (PRBCs) in vessels showed that proportion PRBCs was higher CM than NCM, also organs examined both NCM. Cerebral more tightly packed RBCs those NCM patients, but there no significant difference amount degree endothelial damage numbers pseudopodia. Fibrillar (fibrin) deposits present a small vessels, thrombosis present. There neither acute nor chronic inflammation, leukocytes absent within outside vessels. immune complex deposition Parasites mainly trophozoites schizonts. Occasional RBC remnants following parasite release seen. Some parasites degenerate, resembling crisis forms. adhered to endothelium via surface knobs. It is concluded evidence an inflammatory human malaria clinical effects probably relate anoxia metabolic activities parasites.