Evolution of the Dog Genome
作者： Matthew T Webster , Elinor K Karlsson
DOI: 10.1002/9780470015902.A0021780
关键词:
摘要: The dog genome illuminates several important features of mammalian evolution. is a distant relative to the primate and rodent clades, so its sequence can be used identify genetic changes that occurred on these lineages as an aid in annotating human genome. also has complex population history, shaped by ancient domestication events and, recently, strong artificial selection form distinct breeds. enabled studies shed light canid phylogeny, revealing this history created genomic haplotype structure highly amenable association mapping. Dogs exhibit enormous phenotypic variation suffer from many same disorders humans, making them powerful model organism for identifying variants responsible common traits diseases including cancer, diabetes, autoimmune epilepsy. Key concepts: The distantly related clades. Dog evolution was characterized with large number chromosomal fissions low activity transposons. Genetic evidence supports origin dogs East Asia. Dog involved two bottlenecks, one during domestication, over 15 000 years ago, formation modern breeds past few hundred years. Modern remarkable diversity increased rates shared epilepsy. Patterns are trait mapping studies. Keywords: molecular evolution; population genetics; association studies; domestication; dog breeds; artificial
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