Metronomic chemotherapy: principles and lessons learned from applications in the treatment of metastatic prostate cancer.

摘要: By frequent and protracted administration of conventional cytotoxic drugs without prolonged interruptions, the primary treatment target shifts from tumor cell population to vasculature. This “metronomic” way chemotherapy results in antivascular effects, mechanistic basis which remains be fully elucidated. We outline basic aspects metronomic concept, describe clinical applications such by focusing on studies metastatic prostate cancer, discuss certain shortcomings. Based preclinical findings, we finally point possible ways address these shortcomings order bring this novel promising use anticancer agents full fruition.