Angiogenesis in gliomas: imaging and experimental therapeutics.

摘要: Much of the interest in angiogenesis and hypoxia has led to investigating diagnostic imaging methodologies developing efficacious agents against gliomas. In many ways, because cytostatic effects these on tumor growth tumor-associated endothelial cells, therapy are not immediately evident. Hence finding clinically applicable tools pathologic surrogate markers is an important step translating glioma biology therapeutics. There a variety strategies approach experimental therapeutics that target hypoxia-inducible factor pathway, endogenous antiangiogenic proangiogenic factors their receptors, adhesion molecules, matrix proteases cytokines, existing vasculature. We discuss rationale for antiangiogenesis as treatment strategy, preclinical clinical assessment interventions finally focus various strategies, including combining drugs with radiation chemotherapy.