Early and long-term outcomes of mitral valve repair for Barlow's disease: a single-centre 16-year experience.

摘要: OBJECTIVES Following mitral valve repair for Barlow's disease, recurrent regurgitation (MR) is believed to occur frequently and mainly attributed disease progression. METHODS Between January 2000 December 2015, 180 patients (40% women, mean age 58.7 ± 13.5 years) with underwent repair. To provide a longitudinal assessment of durability, multistate model interval-censored observations (4 states: 1, Grade 0/1+ MR; 2, 2+ 3, 3+/4+ 4, reintervention/death) was developed. The mechanism MR assessed echocardiographically. RESULTS Early mortality 1.7%. After hospital discharge, 6 late reinterventions were performed. With death as competing risk, the 10-year overall reintervention-free survival reintervention rates 79.8% (95% confidence interval 72.7-87.6%) 4.5% 2.0-10.2%), respectively. Echocardiographic follow-up available 165 (93%) survivors total 480 examinations. incidence both relatively low up 10 years after surgery. did not always progress higher grade during period. highly associated valve-related morbidity mortality. Recurrent (≥Grade 2+) predominantly related technical aspects CONCLUSIONS Despite complex abnormalities observed in can be performed good early outcomes recurrence durability remains stable over time, suggesting that underlying progression has limited clinical significance.