Effects of Quercetin Supplementation on Innate Immune Function and Inflammation in Female Human Subjects

摘要: PURPOSE: Quercetin, a flavonoid found in fruits and vegetables, is strong antioxidant with anti-inflammatory, antimicrobial, immune-modulating properties. The purpose of this study was to investigate the effects long-term quercetin supplementation on innate immune function inflammation human subjects. STUDY DESIGN: Female subjects (N=120, ages 30-79 years) were recruited from community randomized one three groups, supplements administered using double-blinded procedures: Q-500 (500 mg/day quercetin, N=38), Q-1000 (1000 N=40), or placebo (N=42). Subjects ingested two soft chew twice daily during twelve-week period. Fasting blood samples obtained pre- post-study analyzed for plasma interleukin (IL)-6, tumor necrosis factor (TNF)-a, leukocyte subset cell counts. Natural killer activity (NKCA) lymphocyte subsets assessed seventy-four subjects. Granulocyte oxidative burst (GOBA) phagocytosis sixty-four Eighteen had overlapping data. RESULTS: Quercetin at 500 1000 increased (interaction effect, P<0.001) compared but no significant influence concentration, IL-6 TNF-a NKCA, GOBA, granulocyte phagocytosis. NKCA inversely correlated BMI (r=-0.25, P=0.035) body fat percentage (r=-0.38, P=0.001), positively self-reported physical fitness level (r=0.24, P=0.032). CONCLUSIONS: Results double-blinded, placebo-controlled, trial indicate that twelve weeks significantly levels measures community-dwelling adult females.