Engineered Biological Entities for Drug Delivery and Gene Therapy

摘要: The development of genetic engineering techniques has speeded up the growth biotechnological industry, resulting in a significant increase number recombinant protein products on market. deep knowledge function, structure, biological interactions, and possibility to design new polypeptides with desired activities have been main factors involved intensive research preclinical clinical approaches. Consequently, entities added value for innovative medicines such as increased stability, improved targeting, reduced toxicity, among others obtained. Proteins are complex nanoparticles sizes ranging from few nanometers hundred when supramolecular interactions occur, example, viral capsids. However, even though production is delicate process that imposes use sophisticated analytical methods negative secondary effects detected some cases immune inflammatory reactions, great potential biodegradable tunable indicates protein-based expected years come.