Insights into the Cellular Trafficking of Prion Proteins
作者： Max Nunziante , Sabine Gilch , Hermann M. Schätzl
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摘要: The detailed understanding of the trafficking and subcellular localization cellular prion protein (PrPc) will contribute to a better conversion process might provide new insights into possible functions PrPc. It has been known for many years that preceding cell surface PrPc appears be required pathological isoform PrPSc in prion-infected cells1,2. Recently, often unexpected findings biology PrPc, pathogenesis PrPSc, quality control mechanisms have accumulating. Many these were obtained by analysing proteins culture models, either presence or absence infectious prions.
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