Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast-conserving therapy.

摘要: Asians are diagnosed with breast cancer at a younger age than Caucasians are. We studied the effect of on locoregional recurrence and survival Asian patients treated breast-conserving therapy. Medical records 2492 therapy between 1989 2012 were reviewed. The Kaplan–Meier method was used to estimate recurrence, cancer-free survival, cancer-specific rates. These rates then compared using log-rank tests. Outcomes modeled by Cox proportional hazards. Fractional polynomials test for non-linear relationships outcomes. Patients ≤ 40 years old more likely have older (Hazard ratio [HR] = 2.32, P < 0.001). Locoregional decreased year-on-year 4% luminal-type cancers, 8% those triple-negative cancers. Similarly, increased versus respectively. Breast 5% year-on-year. Both in luminal cancers exhibited (“L-shaped”) relationship—where decreasing presentation associated escalating risks relapse death. influence overall confounded competing non-cancer deaths women, resulting “U-shaped” relationship. Young continuous increase disease no apparent threshold.