Targeting miR-21 for the Therapy of Pancreatic Cancer

摘要: Despite tremendous efforts worldwide from clinicians and cancer scientists, pancreatic ductal adenocarcinoma (PDA) remains a deadly disease for which no cure is available. Recently, microRNAs (miRNAs) have emerged as key actors in carcinogenesis we demonstrated that microRNA-21 (miR-21), oncomiR expressed early during PDA. In the present study, asked whether targeting miR-21 human PDA-derived cell lines using lentiviral vectors (LVs) may impede tumor growth. We LVs-transduced PDA efficiently downregulated expression, both vitro vivo. Consequently, proliferation was strongly inhibited died by apoptosis through mitochondrial pathway. vivo, depletion stopped progression of very aggressive model PDA, to induce death apoptosis; furthermore, combining chemotherapeutic treatment provoked regression. demonstrate herein first time oncogenic miRNA inhibit growth Because overexpressed most tumors; therapeutic delivery antagonists still be beneficial large number cancers