Beneficial effects of cardiac chymase inhibition during the acute phase of myocardial infarction

摘要: Recently, the presence of chymase-dependent angiotensin (Ang) II-generating system in hamsters, dogs, monkeys, as well human cardiovascular tissues has been identified. We have reported that activation cardiac chymase was more prominent than converting enzyme (ACE) and AT1 receptor antagonist treatment rather ACE inhibitor alone provided significant beneficial effects on function survival after MI hamsters. The aim present study to determine whether this different between were due hamsters by using 4-[1-[[bis-(4-methyl-pheny)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), a novel, orally active specific inhibitor. activities infarcted left ventricle significantly increased 3 days MI. BCEAB (100 mg/kg/day, p.o.) starting before suppressed activity, while it did not affect plasma A improvement hemodynamics (maximal negative positive rates pressure development; ventricular systolic pressure) observed for with reduced mortality rate during 14 observation following (vehicle, 61.1%, n = 18; BCEAB, 27.8%, P < 0.05). These findings demonstrated first time participates directly pathophysiologic state