Cortical iron disrupts functional connectivity networks supporting working memory performance in older adults.
作者： Valentinos Zachariou , Christopher E. Bauer , Elayna R. Seago , Flavius D. Raslau , David K. Powell
DOI: 10.1016/J.NEUROIMAGE.2020.117309
关键词:
摘要: Excessive brain iron negatively affects working memory and related processes but the impact of cortical on task-relevant, networks is unknown. We hypothesized that high concentration may disrupt functional circuitry within supporting performance. Fifty-five healthy older adults completed an N-Back paradigm while magnetic resonance imaging (fMRI) was performed. Participants also underwent quantitative susceptibility mapping (QSM) for assessment non-heme concentration. Additionally, pseudo continuous arterial spin labeling scans were obtained to control potential contributions cerebral blood volume structural images used volume. Task performance positively correlated with strength task-based connectivity (tFC) between regions frontoparietal network. However, higher associated lower tFC this network poorer after controlling both flow Our results suggest disrupts communication reduced in adults.
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