Antifungal nanofibers made by controlled release of sea animal derived peptide

摘要: Candida albicans is a common human-pathogenic fungal species with the ability to cause several diseases including surface infections. Despite clear difficulties of control, antimicrobial peptides (AMPs) have emerged as an alternative strategy for control. In this report, different concentrations antifungal Cm-p1 (Cencritchis muricatus peptide 1) were electrospun into nanofibers drug delivery. The characterized by mass spectrometry confirming presence on scaffold. Atomic force microscopy and scanning electronic used measure diameters, showing that affects fiber morphology well diameter scaffold thickness. release behavior from demonstrated 30 min three days, leading effective yeast control in first 24 hours. Moreover, biocompatibility fibers evaluated through MTS assay ROS production using HUVEC model, do not affect cell viability only containing 10% Cm-p1–PVA improved generation. addition, secretion pro-inflammatory cytokines IL-6 TNF-α HUVECs was also slightly modified nanofibers. conclusion, electrospinning technique applied here allowed manufacture biodegradable biomimetic nanofibrous extracellular membranes infection.