Marine Organisms and Their Prospective Use in Therapy of Human Diseases
作者： Sherif S. Ebada , Peter Proksch
DOI: 10.1007/978-3-642-19382-8_7
关键词:
摘要: Marine ecosystems show remarkable chemical, biological, and ecological diversities which have inspired marine natural product chemists for many years to identify novel chemical entities possessing potent pharmacological activities that could be eventually developed into therapeutics human diseases such as cancer, analgesia, microbial infections, allergy, immune diseases. By 1974, cytarabine (Ara-C, Cytosar-U®) vidarabine (Ara-A, Vira-A®) were the first two marine-derived pharmaceuticals in US pharmacopeia treat Since then, it took more than three further decades introduce next drugs namely ω-conotoxin MVIIA (ziconotide, Prialt®), was approved December 2004 an analgesic against severe chronic pain, ecteinascidin (ET-743, Yondelis®) October 2007 treatment of advanced soft tissue sarcomas, drug market. In addition other products are presently either clinical or preclinical trial phases.
springer.com
springerlink.com参考文章(203)
Alejandro M. S. Mayer, Virginia K. B. Lehmann, Marine pharmacology in 1999: antitumor and cytotoxic compounds. Anticancer Research. ,vol. 21, pp. 2489- 2500 ,(2001)
Werner Bergmann, CONTRIBUTIONS TO THE STUDY OF MARINE PRODUCTS Journal of Biological Chemistry. ,vol. 104, pp. 317- 328 ,(1934) , 10.1016/S0021-9258(18)74505-5
George R. Pettit, Andrew S. Kraft, William H. Benjamin, Pradip Rustagi, Roger L. Berkow, Larry Schlabach, Robert Dodson, In Vivo Administration of the Anticancer Agent Bryostatin 1 Activates Platelets and Neutrophils and Modulates Protein Kinase C Activity Cancer Research. ,vol. 53, pp. 2810- 2815 ,(1993)
D. Mendola, Aquacultural Production of Bryostatin 1 and Ecteinascidin 743 Karger Publishers. pp. 120- 133 ,(2000) , 10.1159/000062482
Ruoli Bai, Susan J. Friedman, George R. Pettit, Ernest Hamel, Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia: Interaction with tubulin and effects on cellular microtubules Biochemical Pharmacology. ,vol. 43, pp. 2637- 2645 ,(1992) , 10.1016/0006-2952(92)90153-A
Yuji Takebayashi, Philippe Pourquier, Drazen B. Zimonjic, Kentaro Nakayama, Steffen Emmert, Takahiro Ueda, Yoshimasa Urasaki, Atsuko Kanzaki, Shin-ichi Akiyama, Nicholas Popescu, Kenneth H. Kraemer, Yves Pommier, Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair Nature Medicine. ,vol. 7, pp. 961- 966 ,(2001) , 10.1038/91008
Charles D. Smith, Xinqun Zhang, Mechanism of Action of Cryptophycin INTERACTION WITH THE Vinca ALKALOID DOMAIN OF TUBULIN Journal of Biological Chemistry. ,vol. 271, pp. 6192- 6198 ,(1996) , 10.1074/JBC.271.11.6192
R.L. Bai, K.D. Paull, C.L. Herald, L. Malspeis, G.R. Pettit, E. Hamel, Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. Journal of Biological Chemistry. ,vol. 266, pp. 15882- 15889 ,(1991) , 10.1016/S0021-9258(18)98491-7
Mauricio Rosas-Ballina, Richard S. Goldstein, Margot Gallowitsch-Puerta, Lihong Yang, Sergio Iván Valdés-Ferrer, Nirav B. Patel, Sangeeta Chavan, Yousef Al-Abed, Huan Yang, Kevin J. Tracey, The Selective α7 Agonist GTS-21 Attenuates Cytokine Production in Human Whole Blood and Human Monocytes Activated by Ligands for TLR2, TLR3, TLR4, TLR9, and RAGE Molecular Medicine. ,vol. 15, pp. 195- 202 ,(2009) , 10.2119/MOLMED.2009.00039
B.M. Olivera, ω-Conotoxin MVIIA: From Marine Snail Venom to Analgesic Drug Karger Publishers. pp. 74- 85 ,(2000) , 10.1159/000062483