The serotonin-O-sulfate as a potential plasma surrogate biomarker

摘要: According to the latest European regulatory policy a close attention is paid research into use of biomarkers and surrogate markers in development pharmaceuticals. Since early sixties last century when sulphation serotonin was described from which biotransformation product serotonin-O-sulfate (5-HT-SO4) formed, assumed it accentuates intensity metabolism central nervous system. Not so many researches are done with this compound particularly humans, but taking account serotonin-o-sulfate able reflect pathways has potential be employed as biomarker follow effects specific serotonergic treatment. Hereby we summarize literature evidence 5-HT-SO4 appearance vivo. So far indolemine found animal neurons, endothelial cells, urine  only site detection humans cerebrospinal liquid. Probably due its absence easy accessible body fluids clinical significance thus been lessened. In result our developed suitable liquid chromatography–mass spectrometry (LC-MS) method, neurotransmitter degradation human plasma performed first trial detecting healthy volunteers. earlier hypothised that release emphasizes system metabolism, therefore further necessary define origin plasmatic humans.